New Predictive Equation for Optimal Continuous Positive Airway Pressure in Adult Patients with Obstructive Sleep Apnea

Objective: This study aimed to develop and validate a new continuous positive airway pressure (CPAP) prediction equation compare it with other formulas.Material Methods: We retrospectively included patients obstructive sleep apnea who underwent CPAP titration between January 2012 December 2016. All clinical polysomnographic data were collected. The was developed using the first set, predictability performance validated second set.Results: Among 266 enrolled patients, 73.7% male, mean body mass index (BMI) 30.8±7.4 kg/m2 . Five variables, namely age, BMI, neck circumference (NC), apnea–hypopnea (AHI), minimum pulse oxygen saturation (Min SpO2 ), highly correlated optimal pressure, therefore in equation, as stated below:Predicted (cm H2 O) = 2.26 + (0.02xAge) (0.04xBMI) (0.11xNC) (0.04xAHI) - (0.04xMin )This accounted for 54.4% of variance predicting (R2 =0.544, p-value <0.001). Its estimation 62.0% group. equation-derived predicted good agreement laboratory-derived (r=0.70, 95% CI=0.6335–0.755, p-value<0.001) according Bland–Altman analysis. Conclusion: Our is consistent fixed thereby beneficial technicians establishing starting such studies at laboratory.